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Findings demonstrate moderate vaccine protection against severe disease in older adults, suggesting increased vaccination is necessary.
These findings demonstrate that the 2024-2025 mRNA COVID-19 vaccine had moderate protection against hospitalization and ED or more severe care, even in a southern US state with a significant rural population and high levels of prior exposure through infection and/or previous vaccination. Given the low vaccine uptake in this population, our results underscore the need for sustained public health efforts to increase vaccination coverage and address the challenges posed by emerging variants, particularly among older adults and those with medical comorbidities.
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Jayawardena et al. (2026) studied this question.
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