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March 5, 2026Acta Neuropathologica Communications0 citationsOpen Access

CUX1::MET Fusion Defines Indolent Diffuse Low-Grade Glioma With MAPK Alterations

CUX1::MET fusion defines an indolent subtype of diffuse low-grade glioma, MAPK pathway–altered

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Authors

HNHiroaki NagashimaYTYasuhide TakeuchiNJNaoe Jimbo

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Overview

Case report highlights an indolent glioma subtype with a CUX1::MET fusion, implying novel biological insights.

Key Points

  • This research investigates the biological significance of the CUX1::MET fusion in diffuse low-grade glioma altered by the MAPK pathway.
  • Case report of a 25-year-old woman with a right temporal lobe tumor
  • Histological examination revealing oligodendroglioma-like features
  • Molecular analysis for genetic alterations, specifically a CUX1::MET fusion
  • Identified a novel CUX1::MET fusion that activates the MAPK pathway
  • The tumor exhibited low-grade features and a low proliferative index
  • Despite MET alteration, the glioma displayed an indolent clinical course over 15 years

Cite This Study

Nagashima et al. (2026) studied this question.

synapsesocial.com/papers/69a91e1fd6127c7a504c1b49https://doi.org/10.1186/s40478-026-02271-5
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