Key result
Baseline NT-proBNP and early post-procedural changes predict 2-year mortality or HF hospitalization after T-TEER.
Why the study?
Does baseline NT-proBNP and its early postprocedural trajectory predict 2-year mortality or heart failure hospitalization in patients undergoing T-TEER for tricuspid regurgitation?
Cohort
Yes
Does baseline NT-proBNP and its early postprocedural trajectory predict 2-year mortality or heart failure hospitalization in patients undergoing T-TEER for tricuspid regurgitation?
Baseline NT-proBNP and its 30-day trajectory are independent predictors of 2-year mortality or heart failure hospitalization after tricuspid valve transcatheter edge-to-edge repair.
Supports NT-proBNP for T-TEER risk stratification; extends established HF biomarker prognostic value to right-sided interventions.
BACKGROUND: N-terminal pro-B-type natriuretic peptide (NT-proBNP) is an established marker of myocardial stress, yet its prognostic role in tricuspid valve transcatheter edge-to-edge repair (T-TEER) for tricuspid regurgitation (TR) remains unclear. OBJECTIVES: The aim of this study was to evaluate the prognostic value of baseline NT-proBNP and its early postprocedural trajectory after T-TEER. METHODS: Patients undergoing T-TEER with available baseline NT-proBNP measurements in the EuroTR (European Registry of Transcatheter Repair for Tricuspid Regurgitation) registry were analyzed. NT-proBNP was evaluated continuously and by tertiles, with longitudinal changes assessed when serial measurements were available. Endpoints were the 2-year composite of all-cause mortality or first heart failure hospitalization, changes in NT-proBNP, symptomatic alleviation, and residual TR. RESULTS: increase: 0.63; 95% CI: 0.48-0.84; P < 0.001). Both baseline NT-proBNP and higher than expected 30-day levels relative to baseline were independently associated with higher subsequent risk for the primary endpoint. CONCLUSIONS: Baseline NT-proBNP was independently associated with 2-year mortality or heart failure hospitalization after T-TEER. Early postprocedural NT-proBNP trajectories provided incremental prognostic information and may identify patients at increased risk.
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Stein et al. (2026) conducted a cohort in Tricuspid regurgitation. Baseline NT-proBNP and early postprocedural trajectory vs. Lower NT-proBNP levels was evaluated on 2-year composite of all-cause mortality or first heart failure hospitalization (0.63, 95% CI 0.48-0.84, p=<0.001). Baseline NT-proBNP and higher than expected 30-day levels were independently associated with higher 2-year risk of mortality or heart failure hospitalization (0.63; 95% CI 0.48-0.84; P<0.001).
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