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March 7, 2026Russian Journal of Preventive Medicine

Studies of the UDP-glucuronosyltransferase enzymes family activity

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Authors

YIYu. V. IvanovaAIA.A. IvanovaVMV.N. Maksimov

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Overview

This review summarizes factors affecting UDP-glucuronosyltransferase activity, indicating implications for drug metabolism.

Key Points

  • This review aims to summarize data on the molecular genetic, epigenetic, and age factors influencing UDP-glucuronosyltransferase enzyme activity.
  • Reviewed Russian publications in Cyberleninka and eLibrary and international papers in PubMed and MEDLINE.
  • Selected studies from the last 10 years related to UGT enzyme activity.
  • Included early papers for their essential data.
  • Identified age-related, genetic, and epigenetic factors that affect the expression and activity of UGT enzymes.
  • Summarized the role of UGT enzymes in metabolizing endogenous and exogenous substances.
  • Highlighted the importance of understanding UGT variability to predict drug reactions.

Cite This Study

Ivanova et al. (2026) studied this question.

synapsesocial.com/papers/69abc2455af8044f7a4ebb1ahttps://doi.org/10.17116/profmed202629021115
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Age‐ and Genotype‐Dependent Variability in the Protein Abundance and Activity of Six Major Uridine Diphosphate‐Glucuronosyltransferases in Human Liver2018 · 121 citations
  2. 2Regulation of DiverseEndogenous Metabolic and SignalingPathways by UDP-Glucuronosyltransferases (UGTs) Revealed by Metabolomicsof Knockout Mice2026
  3. 3Genetic variation in UGT1A1 is not associated with altered liver biochemical parameters in healthy volunteers participating in bioequivalence trials2024 · 2 citations
  4. 4Population-scale variability of the human UDP-glycosyltransferase gene family2024 · 2 citations
  5. 5Association Between UGT1A1 mRNA Expression and Cis-Acting Genetic Variants and Trans-Acting Transcriptional Regulators in Human Liver Samples2025 · 2 citations