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March 8, 2026Cellular and Molecular Life SciencesOpen Access

Acute kidney injury over the past decade: from definition evolution to pathogenesis insights and innovative therapeutic strategies

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Authors

JCJinwen ChenXXXuan XuYCYifang Cai

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Overview

This investigation uncovers insights on AKI pathogenesis and emerging therapeutic strategies, highlighting implications for early diagnosis and treatment.

Key Points

  • To explore the evolution of the definition of acute kidney injury and analyze its pathogenesis and innovative therapeutic approaches.
  • Analysis of the evolving definitions of kidney injury from ARF to AKI and AKD.
  • Examination of the complex pathogenesis involving regulated cell death and inflammation.
  • Review of innovative diagnostic tools and therapeutic strategies, including biomarkers and stem cell therapies.
  • AKI affects about 13.3 million people globally, leading to 1.7 million deaths annually.
  • Innovative diagnostic tools show promise for early detection despite standardization challenges.
  • Emerging therapies like mesenchymal stem cells and anti-inflammatory agents may enhance renal repair.

Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/69ada836bc08abd80d5bb41ehttps://doi.org/10.1007/s00018-026-06104-5
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Acute kidney injury: pathogenesis and therapeutic interventions2025 · 33 citations
  2. 2Discovery Pipeline for AKI: Molecules, Mechanisms, Models, and Targets2025
  3. 3The evolving landscape of acute kidney injury: research directions and changes in clinical practice2026
  4. 4The AKI-CKD Continuum: Mechanisms and Therapeutic Interventions2026 · 1 citations
  5. 5Preventing acute kidney injury in high-risk patients2026