What does this research mean for the field?

Upfront laparoscopic surgery for patients with magnetic resonance imaging-defined cT3 rectal cancer and uninvolved circumferential resection margin yields encouraging long-term oncologic and survival outcomes. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

What question did this study set out to answer?

This research aims to evaluate long-term oncologic and survival outcomes for patients with cT3 rectal cancer who underwent upfront surgery.

March 12, 2026Formosan Journal of SurgeryOpen Access

Long-term outcomes of upfront surgery for magnetic resonance imaging-defined T3 rectal cancer with uninvolved circumferential resection margin

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Authors

HTHung Xuan TranHo Chi Minh City Medicine and Pharmacy University VVVi Tuong Vo TNThinh Huu NguyenHanoi National University of Education

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Implication

Cohort study shows favorable survival outcomes in rectal cancer after upfront surgery, suggesting surgery-first approach in selected patients.

Key Points

This research aims to evaluate long-term oncologic and survival outcomes for patients with cT3 rectal cancer who underwent upfront surgery.
Single-center cohort study including 144 patients with cT3 rectal adenocarcinoma.
All patients had uninvolved circumferential resection margin and negative extramural vascular invasion.
Endpoints assessed included local recurrence, distant metastasis, overall survival, and disease-free survival.
7 patients (4.9%) experienced local recurrence during a median follow-up of 56 months.
15 patients (10.4%) developed distant metastasis, with higher rates in stage III (p = 0.009).
Overall survival rates at 3, 5, and 7 years were 94.4%, 88.2%, and 78.9% respectively.
Disease-free survival rates at 3, 5, and 7 years were 87.5%, 82.3%, and 78.8% respectively.

Cite This Study

Tran et al. (2026) studied this question.

synapsesocial.com/papers/69b25b6496eeacc4fceca05f https://doi.org/10.1097/fs9.0000000000000276

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Implication

Cohort study shows favorable survival outcomes in rectal cancer after upfront surgery, suggesting surgery-first approach in selected patients.

Long-term outcomes of upfront surgery for magnetic resonance imaging-defined T3 rectal cancer with uninvolved circumferential resection margin

Discussion

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Implication

Key Points

Cite This Study

Long-term outcomes of upfront surgery for magnetic resonance imaging-defined T3 rectal cancer with uninvolved circumferential resection margin

Discussion

Member takes

Implication

Key Points

Cite This Study

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