Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 30, 2026International Journal of Cancer

Neoadjuvant Chemotherapy Versus Upfront Surgery for cT2N1 or cT3a ‐ bN0 ‐1 Middle‐High Rectal Cancer

View Full Paper
Ask AI
Bookmark
Share

Authors

JZJiahao ZhouZhejiang Sci-Tech UniversityYSYu ShenSichuan UniversityWHWenyu HuangSichuan University

Discussion

Loading...

Member takes

Implication

Retrospective cohort study examines neoadjuvant chemotherapy versus surgery outcomes in patients with middle-high rectal cancer, suggesting improved disease-free survival.

Key Points

  • To compare survival outcomes of neoadjuvant chemotherapy and upfront surgery in patients with middle-high rectal cancer staged as cT2N1 or cT3a-bN0-1.
  • Retrospective cohort study at West China Hospital from January 2016 to June 2023.
  • 514 patients analyzed; 262 underwent surgery and 252 received neoadjuvant chemotherapy.
  • Propensity score matching resulted in 201 matched pairs for analysis.
  • Neoadjuvant chemotherapy followed by surgery resulted in improved disease-free survival (DF; HR 0.50; 95% CI 0.30-0.83; p=0.008) and metastasis-free survival (MFS; HR 0.50; 95% CI 0.28-0.86; p=0.01).
  • 3-year DFS rates for chemotherapy followed by surgery were 90.5%, while upfront surgery was 81.6%.
  • 3-year MFS rates were 92.0% for the chemotherapy group versus 84.0% for surgery group.

Cite This Study

Zhou et al. (2026) studied this question.

synapsesocial.com/papers/6a6af51f60e2b924d3ea0cddhttps://doi.org/10.1002/ijc.70660
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1NCCN Guidelines® Insights: Rectal Cancer, Version 3.20242024 · 279 citations
  2. 2Rectal Cancer1998 · 1,405 citations
  3. 3Preoperative Versus Postoperative Chemoradiotherapy for Locally Advanced Rectal Cancer: Results of the German CAO/ARO/AIO-94 Randomized Phase III Trial After a Median Follow-Up of 11 Years2012 · 2,155 citations
  4. 4Preoperative Chemotherapy for Operable Colon Cancer: Mature Results of an International Randomized Controlled Trial2023 · 483 citations
  5. 5Preoperative High-resolution Magnetic Resonance Imaging Can Identify Good Prognosis Stage I, II, and III Rectal Cancer Best Managed by Surgery Alone2011 · 662 citations