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March 14, 2026Neuro-Oncology PediatricsOpen Access

MDB-18. A bench-top model for the optimization of ultrasound parameters for sonodynamic therapy of medulloblastoma

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Authors

RHROBERT W. HOVEYBABassam AbdulkarimRDRoberto J. Diaz

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Overview

Evaluates ultrasound effects on tumor cell death in medulloblastoma, suggesting a viable in-vitro model for therapy optimization.

Key Points

  • The central aim is to optimize ultrasound parameters for sonodynamic therapy in medulloblastoma cells.
  • Used a bench-top focused ultrasound device to apply varying ultrasound power and treatment durations.
  • Exposed UW426 medulloblastoma cells to 5-ALA at different concentrations for up to 24 hours.
  • Measured ROS levels and apoptotic markers using FACS after treating cells with different combinations of 5-ALA and FUS.
  • Identified optimal incubation time for peak protoporphyrin IX fluorescence through FACS.
  • Peak PPIX fluorescence achieved after 12 hours with 200 µg/mL 5-ALA.
  • Maximum ROS levels recorded at 0.91 MHz with 120 seconds of sonication at 6 W power.
  • Significant cell death observed at 3 W and 6 W power with sonication durations of 90 and 120 seconds.

Cite This Study

HOVEY et al. (2025) studied this question.

synapsesocial.com/papers/69b4fbb1b39f7826a300c021https://doi.org/10.1093/neuped/wuaf001.217
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  1. 1P07.20.B SONODYNAMIC THERAPY WITH A SINGLE NEOADJUVANT, DIFFUSE DELIVERY OF LOW-INTENSITY ULTRASOUND WITH 5-ALA IN TREATMENT NAÏVE GLIOBLASTOMA RESULTS IN TUMOR-SPECIFIC CYTOTOXIC EDEMA AND INCREASED APOPTOSIS2025
  2. 2Sonodynamic Therapy: Porphyrin-Based Sensitizers and Low-Intensity Ultrasound for Precision Treatment of Glioblastoma2026
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