What does this research mean for the field?

Isolated late-onset depression may represent an early manifestation of sporadic Creutzfeldt-Jakob disease (sCJD) in elderly patients. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

What question did this study set out to answer?

This research aims to highlight the diagnostic challenges of sporadic Creutzfeldt-Jakob disease when it presents with late-onset depression.

March 16, 2026CureusOpen Access

Late-Onset Depression Mimicking a Primary Psychiatric Disorder: Diagnostic Pitfalls in Sporadic Creutzfeldt-Jakob Disease

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This research aims to highlight the diagnostic challenges of sporadic Creutzfeldt-Jakob disease when it presents with late-onset depression.
Case report of a 75-year-old woman
Neurological examinations including MRI and EEG
Cerebrospinal fluid analysis for 14-3-3 protein
Initial presentation of late-onset depression without myoclonus
MRI showed basal ganglia hyperintensity
Positive 14-3-3 protein in CSF analysis
Patient progressed to advanced symptoms consistent with sCJD

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Implication

Case report reveals early psychiatric symptoms as indicators of sporadic Creutzfeldt-Jakob disease in elderly patients, suggesting timely evaluation is vital.

Cite This Study

Abourachida et al. (2026) studied this question.

synapsesocial.com/papers/69b79ea18166e15b153ac3b2 https://doi.org/10.7759/cureus.105209

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Implication

Case report reveals early psychiatric symptoms as indicators of sporadic Creutzfeldt-Jakob disease in elderly patients, suggesting timely evaluation is vital.

Late-Onset Depression Mimicking a Primary Psychiatric Disorder: Diagnostic Pitfalls in Sporadic Creutzfeldt-Jakob Disease

Key Points

Discussion

Implication

Cite This Study

Late-Onset Depression Mimicking a Primary Psychiatric Disorder: Diagnostic Pitfalls in Sporadic Creutzfeldt-Jakob Disease

Key Points

Discussion

Implication

Cite This Study

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