What does this research mean for the field?

Both left and right ventricular endomyocardial biopsies are safe, and while sampling both ventricles optimizes diagnostic yield, MRI-guided biopsy targeting late gadolinium enhancement does not increase the detection of myocarditis. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

August 17, 2010Circulation

Comparative Evaluation of Left and Right Ventricular Endomyocardial Biopsy

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Why the study?

Does preferential biopsy in regions showing late gadolinium enhancement on cardiovascular magnetic resonance increase the number of positive diagnoses of myocarditis?

Population

Patients undergoing endomyocardial biopsy (EMB) for suspected myocarditis

Design

Other

Authors

AYAli YılmazCardiac Imaging IKIngrid KindermannHeart Failure & Transplant MKMichael KindermannUniversitätsklinikum des Saarlandes

Discussion

Member takes

Overview

CMR-guided LGE-targeted EMB should not yet guide practice; leaves open optimal strategies including biventricular sampling.

Structured PICO

Does preferential biopsy in regions showing late gadolinium enhancement on cardiovascular magnetic resonance increase the number of positive diagnoses of myocarditis?

Population

Patients undergoing endomyocardial biopsy (EMB) for suspected myocarditis

Intervention

Left ventricular (LV-EMB) and right ventricular (RV-EMB) endomyocardial biopsy, including preferential biopsy in regions showing late gadolinium enhancement on cardiovascular magnetic resonance

Outcome

Diagnostic yield and number of positive diagnoses of myocarditis

Sampling from both ventricles optimizes the diagnostic yield of endomyocardial biopsy, but CMR-guided preferential biopsy does not increase positive diagnoses of myocarditis.

Cite This Study

Yılmaz et al. (2010) studied this question.

synapsesocial.com/papers/69bbb2a52688e649d33d48a7 https://doi.org/10.1161/circulationaha.109.924167

View Full Paper

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August 17, 2010Circulation

Comparative Evaluation of Left and Right Ventricular Endomyocardial Biopsy

View Full Paper

Ask AI

Bookmark

Why the study?

Does preferential biopsy in regions showing late gadolinium enhancement on cardiovascular magnetic resonance increase the number of positive diagnoses of myocarditis?

Population

Patients undergoing endomyocardial biopsy (EMB) for suspected myocarditis

Design

Other

Authors

AYAli YılmazCardiac Imaging IKIngrid KindermannHeart Failure & Transplant MKMichael KindermannUniversitätsklinikum des Saarlandes

Discussion

Member takes

Overview

CMR-guided LGE-targeted EMB should not yet guide practice; leaves open optimal strategies including biventricular sampling.

Structured PICO

Does preferential biopsy in regions showing late gadolinium enhancement on cardiovascular magnetic resonance increase the number of positive diagnoses of myocarditis?

Population

Patients undergoing endomyocardial biopsy (EMB) for suspected myocarditis

Intervention

Left ventricular (LV-EMB) and right ventricular (RV-EMB) endomyocardial biopsy, including preferential biopsy in regions showing late gadolinium enhancement on cardiovascular magnetic resonance

Outcome

Diagnostic yield and number of positive diagnoses of myocarditis

Sampling from both ventricles optimizes the diagnostic yield of endomyocardial biopsy, but CMR-guided preferential biopsy does not increase positive diagnoses of myocarditis.

Cite This Study

Yılmaz et al. (2010) studied this question.

synapsesocial.com/papers/69bbb2a52688e649d33d48a7 https://doi.org/10.1161/circulationaha.109.924167

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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