Chronic cardiac HIF-1α stabilization drives autonomous pathways that contribute to cardiomyopathy progression.
Caution advised for sustained HIF-1α stabilization; leaves open its role in human cardiomyopathy progression.
Changes induced with transgenic cardiac HIF-1α possibly mediate beneficial effects in the short term; however, with increased mechanical load and ageing they become detrimental for cardiac function. Together with the finding of increased HIF-1α protein levels in samples from human patients with cardiomyopathy, these data indicate that chronic HIF-1α stabilization drives autonomous pathways that add to disease progression.
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Hölscher et al. (2012) studied this question.
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