The HFA-AdvHF definition selects a smaller, higher-risk heart failure group compared to the broader GALACTIC-Severe criteria, which identifies a population with a lower but still high risk.
How do different severe and advanced heart failure definitions (HFA-AdvHF vs. GALACTIC-Severe) compare in prognostic performance among real-world heart failure patients?
The HFA-AdvHF and GALACTIC-Severe criteria identify distinct heart failure populations with varying risk profiles, highlighting NT-proBNP, hospitalization history, and diuretic dose as potential trial enrichment tools.
The HFA-AdvHF definition selected a smaller, high-risk group, while the GALACTIC-Severe criteria identified a broader population, with a lower, but still high risk. NT-proBNP, HF hospitalization history, and diuretic dose might represent valuable enrichment tools for future trials.
Guidetti et al. (2026) studied this question. The HFA-AdvHF definition selects a smaller, higher-risk heart failure group compared to the broader GALACTIC-Severe criteria, which identifies a population with a lower but still high risk.