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January 1, 2026Journal of Materials Chemistry B

A pH-sensitive nanoplatform encapsulating lipid droplets specific near-infrared fluorescent probe for in vivo imaging of mice carotid artery plaques

Ying Zhang Tianyi Qu Fengming Wu Ming Chen Zheng Chai Shufen Li Weihua Zhuang Mao Chen

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Key Points

The aim is to develop a pH-sensitive nanoplatform to track lipid droplets for imaging atherosclerotic plaques.
Developed a nanoplatform encapsulating lipid droplets
Utilized a near-infrared fluorescent probe
Conducted in vivo imaging in mouse models of atherosclerosis
Achieved effective monitoring of lipid droplets in real-time
Enhanced imaging contrast in atherosclerotic plaques
Demonstrated potential for precise diagnosis and monitoring of arterial diseases

Implication

This research demonstrates a new nanoplatform for real-time imaging of atherosclerotic plaques in mice, suggesting promising diagnostic potential.

Abstract

Effective real-time monitoring and tracking of lipid droplets (LDs) are crucial for precise diagnosis of atherosclerotic plaques and surveillance of pathological progression, while there is no effective in vivo LDs...

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Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69c37b93b34aaaeb1a67e0e8 https://doi.org/10.1039/d5tb02936h

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1BODIPY-Based Fluorescent Probes Distinguish the Heterogeneity of Lipid Droplets in Carotid and Femoral Atherosclerotic Plaques2025 · 4 citations
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3Lipid‐Activatable Fluorescent Probe for Intraoperative Imaging of Atherosclerotic Plaque Using In Situ PatchOriginal Research · 2021 · 34 citations
4A lipid droplet‐selective fluorescent probe for real‐time imaging and polarity sensing2025 · 9 citations
5Screening of Drug-Induced Steatosis and Phospholipidosis Using Lipid Droplet-Selective Two-Photon ProbesOriginal Research · 2020 · 59 citations

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