Why the study?
Do blood pressure-lowering drugs prevent recurrent stroke, major vascular events, and dementia in patients with a history of stroke or transient ischaemic attack?
Do blood pressure-lowering drugs prevent recurrent stroke, major vascular events, and dementia in patients with a history of stroke or transient ischaemic attack?
Blood pressure-lowering drugs, particularly ACE inhibitors and diuretics, are effective for secondary prevention of recurrent stroke in patients with a history of stroke or TIA.
Supports BP-lowering drugs for secondary stroke prevention; confirms efficacy while leaving optimal systolic target unresolved.
Our results support the use of BPLDs in people with stroke or TIA for reducing the risk of recurrent stroke. Current evidence is primarily derived from trials studying an ACE inhibitor or a diuretic. No definite conclusions can be drawn from current evidence regarding an optimal systolic blood pressure target after stroke or TIA.
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Zonneveld et al. (2018) studied this question.
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