Refractory hypertension is associated with a high prevalence of target organ damage, highlighting the need for intensive therapeutic approaches to normalize blood pressure.
May prompt enhanced screening for organ damage; hypothesis-generating for interventional trials in refractory hypertension.
Our study suggests that RH is a clinical condition associated with a high prevalence of TOD at cardiac, macro- and microvascular level and consequently with high absolute cardiovascular risk, which needs a particularly intensive therapeutic approach aimed to normalize BP levels and to induce TOD regression.
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Cuspidi et al. (2001) studied this question.
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