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To analyze cardiorespiratory motion of specific cardiac substructures using a novel 5D-MRI workflow.

Deducing cardiorespiratory motion of cardiac substructures using a novel 5D-MRI workflow for radiotherapy

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To analyze cardiorespiratory motion of specific cardiac substructures using a novel 5D-MRI workflow.
Implemented 5D-MRI in 10 healthy subjects and 2 lung cancer patients.
Localized low-rank iterative reconstruction during various breathing phases was conducted.
Cardiac substructures including coronary arteries and chambers were contoured and analyzed for motion.
Cardiac motion exceeded 1 cm for right-heart substructures, with greater motion in the right coronary artery.
Respiratory motion was largest for the inferior vena cava and left ventricle.
Statistically significant differences in motion were found between various cardiac substructures.

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5D-MRI workflow assesses cardiac and respiratory motion in subjects, suggesting improved treatment planning for radiotherapy.

Ruff et al. (2026) studied this question.

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