Key result
Respiration caused cardiac substructure displacements up to 17.9 mm and varied the mean dose to the left anterior descending artery by 3.03 ± 1.75 Gy, which was missed by whole heart metrics.
Why the study?
Whole-heart dose metrics are not as strongly linked to late cardiac morbidities as radiation doses to individual cardiac substructures, creating a need to characterize substructure excursion throughout respiration.
Observational (n=11)
Cardiac substructures experience significant displacement during respiration, highlighting the need for substructure-specific margins to improve cardiac sparing in thoracic radiation therapy.
No takes yet. Share an insight, caveat, or question.
Respiration-induced LAD dose variation missed by whole-heart metrics may affect cardiotoxicity risk; hypothesis-generating for substructure-guided planning.
Miller et al. (2021) conducted an observational in Cancer in the thorax (breast and thoracic cancer) (n=11). Respiration was evaluated on Excursion and dosimetric variation of sensitive cardiac substructures. Respiration caused cardiac substructure displacements up to 17.9 mm and varied the mean dose to the left anterior descending artery by 3.03 ± 1.75 Gy, which was missed by whole heart metrics.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: