Efficacy comparison of dapagliflozin combined with liraglutide versus monotherapy in obese patients with heart failure

This study aimed to evaluate the efficacy and safety of dapagliflozin combined with liraglutide versus monotherapy in obese patients with heart failure with preserved ejection fraction (HFpEF). This retrospective study enrolled 360 obese patients with HFpEF, who were divided into 3 groups according to different treatment methods: the combination group (dapagliflozin + liraglutide), the dapagliflozin group, and the liraglutide group, with 120 patients in each group. The intervention duration was 24 weeks. The primary endpoints included changes in N-terminal pro-B-type natriuretic peptide levels, 6-minute walk distance, and cardiac structural parameters. Secondary endpoints included metabolic indicators (weight, blood glucose, etc) and safety outcomes. After 24 weeks of intervention, the combination group showed a more significant decrease in B-type natriuretic peptide levels ( P < .05) and a greater improvement in 6-minute walk distance ( P < .05) compared with the 2 monotherapy groups. In terms of metabolic indicators, the combination group had greater weight loss ( P < .05) and better blood glucose control ( P < .05). The incidence of major cardiovascular composite endpoints in the combination group was lower than that in the monotherapy groups ( P < .05). The overall incidence of adverse events was similar among the 3 groups ( P > .05). Dapagliflozin combined with liraglutide has a synergistic effect in improving cardiac function and metabolic disorders in obese patients with HFpEF, with good safety, providing a more effective therapeutic strategy for clinical practice.