Key result
Diabetes linked to ~225% higher odds of in-hospital MACE following PCI.
Why the study?
Although PCI is extensively used for coronary artery disease, patient demographics and cardiovascular risk factors continue to impact procedural and clinical results.
Observational (n=270)
No
Effect estimate: OR 3.25 (95% CI 1.50-7.05)
Absolute Event Rate: 12.5% vs 3.33%
p-value: p=0.003
Advanced age and diabetes mellitus are significant independent predictors of adverse in-hospital outcomes following PCI, emphasizing the need for targeted risk stratification in these vulnerable populations.
Warrants targeted risk stratification after PCI in patients ≥60 with diabetes; reinforces their independent link to in-hospital MACE.
Background: Percutaneous coronary intervention (PCI) is extensively employed for the therapy of coronary artery disease; nonetheless, patient demographics and cardiovascular risk factors continue to impact procedural and clinical results Objective: To evaluate the association between patient demographics and cardiovascular risk factors and in-hospital clinical outcomes, including major adverse cardiovascular events (MACE), stent thrombosis, and mortality, among patients undergoing PCI. Methodology: This hospital-based observational study was conducted over a one-year period from July 2023 to June 2024. A total of 270 adult patients undergoing elective or emergency PCI were enrolled using a convenience sampling technique. Data on demographic characteristics, cardiovascular risk factors, procedural details, and in-hospital outcomes were collected using a structured proforma designed by hospital staff and research investigators. Statistical analysis was performed using SPSS version 26 (IBM Corp., Armonk, New York, USA), including chi-square tests, independent-samples t-tests, and multivariate logistic regression to identify independent predictors of adverse outcomes. Results: Of the 270 patients, 185 (68.52%) were male and 93 (34.44%) were aged ≥60 years. Hypertension was present in 158 (58.52%) patients, and diabetes mellitus in 120 (44.44%) patients. Procedural success was achieved in 250 (92.59%) cases, while in-hospital major adverse cardiovascular events (MACE) occurred in 20 (7.41%), stent thrombosis in 8 (2.96%), and mortality in 5 (1.85%) patients. Patients who developed MACE were significantly older than those with procedural success (61.7 ± 9.5 vs. 55.3 ± 10.2 years; p = 0.034). Multivariate analysis identified age ≥60 years (adjusted OR: 2.10; p = 0.035) and diabetes mellitus (adjusted OR: 3.25; p = 0.003) as independent predictors of adverse PCI outcomes. Conclusion: Advanced age and diabetes mellitus were significant determinants of adverse in-hospital outcomes following PCI despite high overall procedural success rates.
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Ali et al. (2026) conducted an observational in Coronary artery disease (n=270). Diabetes mellitus (Risk Factor) vs. No diabetes mellitus was evaluated on In-hospital major adverse cardiovascular events (MACE) (OR 3.25, 95% CI 1.50-7.05, p=0.003). Diabetes mellitus and age ≥60 years independently increased the odds of in-hospital major adverse cardiovascular events following PCI by 3.25 and 2.10 times, respectively.
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