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April 1, 2026PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS

Ionizing Radiation-induced Lens Injury: Epidemiology, Dose-effect Relationship, and Molecular Mechanisms

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Authors

CHCheng-Hao HuSRShao-Han RENHZHai-tao Zhang

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Overview

This review examines lens injury from ionizing radiation, linking epidemiology to molecular mechanisms, indicating critical health implications.

Key Points

  • The aim is to synthesize knowledge on ionizing radiation-induced lens injury, focusing on epidemiology, dose-response relationships, and molecular mechanisms.
  • Analyzed epidemiological exposure characteristics through dose, time, space, and population dimensions.
  • Reviewed clinical evidence related to radiation cataracts and latency periods.
  • Evaluated dose-effect relationships, challenging traditional thresholds with emerging linear non-threshold concepts.
  • Assessed molecular mechanisms including DNA damage, antioxidant dysfunction, and cell cycle disruption.
  • Radiation cataracts show distinct latency inversely correlated with dose, relevant in low-dose occupational settings.
  • Evidence suggests potential linear non-threshold relationship for cataract risk rather than fixed dose thresholds.
  • DNA damage, oxidative stress, and altered cell behavior are key in radiation-induced opacification.

Cite This Study

Hu et al. (2026) studied this question.

synapsesocial.com/papers/69ccb59f16edfba7beb8768bhttps://doi.org/10.3724/j.pibb.2025.0438
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Essence of Radiogenic Damages in the Lens: Threshold, Tissue Reactions (Deterministic Effects), but not Stochastic, Non-Threshold Effects2024
  2. 2Critical Review of Cataractogenesis and Lens Contouring in Radiation Oncology2026
  3. 3Intermediate risk factors in ionising radiation cataractogenesis2026
  4. 4Non-cancer effects of radiation exposure: Cataracts, diseases of the circulatory system, and beyond2026
  5. 5ANovel Framework of an Adverse Outcome Pathway Targetingthe Eye Lens: Mechanistic Insights from 4,5-Dichloro-2- <i>n</i> -octyl-4-isothiazolin-3-one (DCOIT) Exposure inCataract Etiology2026