Why the study?
Does an ACE-I based regimen disproportionately lower central blood pressure compared to a diuretic-based regimen in older hypertensive subjects?
Population
479 older hypertensive subjects from the Second Australian National Blood Pressure Trial cohort, mean age…
Comparison
Angiotensin-converting enzyme inhibitor based… vs Diuretic-based regimen for 4 years
Design
RCT, Randomly assigned
Follow-up
4 years
Authors
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ACE-I and diuretic regimens lower central BP equivalently in older hypertensives; does not explain ACE-I prognostic advantage.
Does an ACE-I based regimen disproportionately lower central blood pressure compared to a diuretic-based regimen in older hypertensive subjects?
The better prognosis observed with ACE-inhibitors compared to diuretics in older hypertensive patients is not explained by a disproportionate lowering of central blood pressure.
Dart et al. (2007) studied this question.
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