Why the study?
Does angiotensin-converting enzyme inhibitor-based treatment reduce total cardiovascular events compared to diuretic-based treatment in elderly hypertensive patients?
Population
6,000 hypertensive subjects 65-84 years of age
Comparison
Angiotensin-converting enzyme inhibitor-based… vs Diuretic-based treatment
Design
RCT, prospective randomized, open-label design with blinding of endpoint…
Follow-up
5 years
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Protocol for ANBP2 RCT published; leaves open whether ACE inhibitor- or diuretic-based therapy better reduces CV events in elderly hypertension until results emerge.
Does angiotensin-converting enzyme inhibitor-based treatment reduce total cardiovascular events compared to diuretic-based treatment in elderly hypertensive patients?
This paper describes the protocol for the ANBP2 trial, which aims to compare ACE inhibitor-based versus diuretic-based treatment for hypertension in the elderly.
A 1997 study studied this question.