Why the study?
Do ACE inhibitors or calcium antagonists reduce cardiovascular morbidity and mortality compared to beta-blockers and diuretics in elderly hypertensives?
Population
6628 hypertensive men and women aged 70-84 at 312 Swedish health centres. 11% diabetics, 9% smokers.
Comparison
ACE inhibitors or calcium antagonists vs beta-blockers and diuretics
Design
RCT, centralized randomization, open trial with blinded end-point committee
Follow-up
1 year (progress report)
Authors
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Confirms trial feasibility with expected events in elderly hypertensives; leaves open comparative outcomes of newer versus older regimens.
Do ACE inhibitors or calcium antagonists reduce cardiovascular morbidity and mortality compared to beta-blockers and diuretics in elderly hypertensives?
This progress report of the STOP-Hypertension-2 trial demonstrates successful recruitment and expected event rates, setting the stage for comparing newer vs older antihypertensive regimens in elderly patients.
Lindholm et al. (1996) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: