Key result
Newer antihypertensive drugs did not differ from conventional therapy for cardiovascular mortality, but reduced all stroke by 25% (95% CI 0.58-0.97; p=0.027).
Why the study?
Does newer antihypertensive therapy (ACE inhibitors or calcium antagonists) reduce cardiovascular mortality and morbidity compared to conventional therapy (diuretics or beta-blockers) in elderly patients with isolated systolic hypertension?
RCT (n=2,280)
randomized
Does newer antihypertensive therapy (ACE inhibitors or calcium antagonists) reduce cardiovascular mortality and morbidity compared to conventional therapy (diuretics or beta-blockers) in elderly patients with isolated systolic hypertension?
In elderly patients with isolated systolic hypertension, newer antihypertensive drugs (ACE inhibitors or calcium antagonists) reduced stroke risk by 25% compared to conventional therapy (diuretics or beta-blockers), despite similar blood pressure lowering and cardiovascular mortality.
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Supports preferring newer antihypertensives for stroke prevention in elderly ISH; extends randomized evidence beyond BP equivalence.
Ekbom et al. (2004) conducted an RCT in isolated systolic hypertension (n=2,280). Newer antihypertensive drugs (ACE inhibitors or calcium antagonists) vs. Conventional antihypertensive therapy (beta-blockers or diuretics) was evaluated on cardiovascular mortality. Newer antihypertensive drugs did not differ from conventional therapy for cardiovascular mortality, but reduced all stroke by 25% (95% CI 0.58-0.97; p=0.027).
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