Why the study?
Does monotherapy with ACE inhibitors, beta-blockers, calcium blockers, or diuretics most effectively lower systolic blood pressure in elderly patients with previously untreated hypertension?
Population
74 elderly patients with previously untreated systolic hypertension (SBP > 150 mm Hg after three visits)
Comparison
Low and high dose of ACE inhibitors… vs Placebo for 1 month
Design
RCT, Balanced, randomized crossover design
Follow-up
1 month per period (5 periods total)
Authors
Loading...
Supports preferring CCBs or diuretics as initial monotherapy in elderly hypertension; confirms class-specific SBP reductions in RCT evidence.
Does monotherapy with ACE inhibitors, beta-blockers, calcium blockers, or diuretics most effectively lower systolic blood pressure in elderly patients with previously untreated hypertension?
In elderly patients with systolic hypertension, diuretics and calcium-channel blockers are more effective than ACE inhibitors and beta-blockers at lowering systolic blood pressure, though combination therapy is usually required to achieve target goals.
T Morgan (2001) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: