What question did this study set out to answer?

To assess the efficacy and safety of active blood pressure-lowering therapy versus placebo in reducing cardiovascular morbidity and mortality among elderly patients with hypertension.

January 1, 1993Clinical and Experimental Hypertension

Swedish Trial in Old Patients with Hypertension (Stop-Hypertension) Analyses Performed up to 1992

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Why the study?

Does active antihypertensive therapy reduce cardiovascular endpoints, stroke, and mortality in elderly patients with hypertension?

Key Points

To assess the efficacy and safety of active blood pressure-lowering therapy versus placebo in reducing cardiovascular morbidity and mortality among elderly patients with hypertension.
Randomized, prospective, placebo-controlled study including 1,627 men and women aged 70–84 years with supine blood pressure ≥ 180/105 mmHg, excluding those with isolated systolic hypertension.
Participants received active therapy with three beta-blockers and one diuretic (frequently combined to achieve a goal blood pressure of < 160/95 mmHg) or placebo, with an average follow-up of 25 months (3,390 patient-years).
Active therapy lowered supine blood pressure from 195/102 mmHg to 167/87 mmHg at the longest follow-up compared to placebo.
Active treatment produced significant relative reductions in all primary cardiovascular endpoints (-40%, p = 0.0031), fatal and non-fatal stroke (-47%, p = 0.0081), and all-cause mortality (-43%, p = 0.0079).
Substantial benefits were observed for secondary endpoints such as heart failure, with maintained tolerability and equivalent risk reduction across men and women.

Structured PICO

Does active antihypertensive therapy reduce cardiovascular endpoints, stroke, and mortality in elderly patients with hypertension?

Population

1,627 men and women aged 70-84 years with a supine blood pressure ≥ 180/105 mmHg (and/or) but not isolated systolic hypertension.

Intervention

Active antihypertensive therapy (three beta-blockers and one diuretic used as blood pressure lowering agents).

Comparator

Placebo.

Outcome

All cardiovascular primary endpoints, fatal and non-fatal stroke, and total mortality.hard clinical

Antihypertensive treatment in elderly patients significantly reduces cardiovascular morbidity and mortality, including stroke and total mortality.

Discussion

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Implication

Supports antihypertensive therapy in elderly hypertensives; confirms CV event and mortality reductions in this population.

Cite This Study

Dahlöf et al. (1993) studied this question.

synapsesocial.com/papers/6a766205c75cd09d33475796 https://doi.org/10.3109/10641969309037082

Topics

Hypertension management

View Full Paper

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Swedish Trial in Old Patients with Hypertension (Stop-Hypertension) Analyses Performed up to 1992

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

Swedish Trial in Old Patients with Hypertension (Stop-Hypertension) Analyses Performed up to 1992

Key Points

Structured PICO

Discussion

Implication

Cite This Study

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