Key result
Newer antihypertensive therapies (ACE inhibitors and calcium antagonists) showed no significant differences in the risk of cardiovascular events compared to conventional therapy in elderly patients.
Why the study?
Do newer antihypertensive therapies (ACE inhibitors or calcium antagonists) reduce cardiovascular mortality and morbidity compared to established therapies (beta-blockers and diuretics) in elderly hypertensive patients?
RCT (n=6,614)
Do newer antihypertensive therapies (ACE inhibitors or calcium antagonists) reduce cardiovascular mortality and morbidity compared to established therapies (beta-blockers and diuretics) in elderly hypertensive patients?
Newer antihypertensive therapies (ACE inhibitors and calcium antagonists) are as effective as conventional therapies (beta-blockers and diuretics) in preventing cardiovascular events in elderly hypertensive patients.
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Permits individualized selection by tolerability or cost in elderly hypertensives; confirms equivalent cardiovascular event prevention versus conventional therapy.
Lennart Hansson (2000) conducted an RCT in Hypertension (n=6,614). Newer antihypertensive therapies (ACE inhibitors and calcium antagonists) vs. Established therapies (beta-blockers and diuretics) was evaluated on Combination of fatal stroke, fatal myocardial infarction and other fatal cardiovascular disease. Newer antihypertensive therapies (ACE inhibitors and calcium antagonists) showed no significant differences in the risk of cardiovascular events compared to conventional therapy in elderly patients.
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