Key result
ACE inhibitors and calcium antagonists reduced blood pressure and cardiovascular events to the same extent as conventional therapy with beta-blockers and diuretics in elderly hypertensive patients.
Why the study?
Do ACE inhibitors and calcium antagonists reduce cardiovascular events similarly to conventional therapy with beta-blockers and diuretics in elderly hypertensive patients?
RCT
Do ACE inhibitors and calcium antagonists reduce cardiovascular events similarly to conventional therapy with beta-blockers and diuretics in elderly hypertensive patients?
The STOP-Hypertension-2 trial results support the 1999 WHO/ISH guidelines, showing that blood pressure lowering per se, rather than specific drug classes, drives cardiovascular event reduction in elderly patients.
No takes yet. Share an insight, caveat, or question.
Supports BP lowering per se as the driver of CV benefit in elderly hypertension; leaves open class-specific effects beyond BP reduction.
Lars Lindholm (2000) conducted an RCT in Hypertension. ACE inhibitors and calcium antagonists vs. Conventional therapy with beta-blockers and diuretics was evaluated on Cardiovascular events. ACE inhibitors and calcium antagonists reduced blood pressure and cardiovascular events to the same extent as conventional therapy with beta-blockers and diuretics in elderly hypertensive patients.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: