September 23, 2020Open Access

Prognostic importance of the transmitral pressure gradient in mitral annular calcification with associated mitral valve dysfunction

Structured PICO

Does mean transmitral gradient predict mortality in patients with MAC-related mitral valve dysfunction?

Population

Patients with mitral annular calcification (MAC)-related mitral valve dysfunction

Intervention

Mean transmitral gradient

Comparator

Lower vs higher transmitral gradients

Outcome

Mortalityhard clinical

Mean transmitral gradient provides prognostic utility for mortality in MAC-related mitral valve dysfunction, independent of mitral regurgitation severity at higher gradients.

Abstract

In MAC-related mitral valve dysfunction, mean transmitral gradient is associated with increased mortality after adjustment for age, sex, and MAC-related risk factors. Concomitant MR is associated with excess mortality in low-gradient ranges (3-5 mmHg) but gradually loses prognostic importance at higher gradients, indicating prognostic utility of transmitral gradient in MAC regardless of MR severity.

Prognostic importance of the transmitral pressure gradient in mitral annular calcification with associated mitral valve dysfunction

Structured PICO

Abstract

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