Why the study?
Do impaired LV systolic function and transmural LGE predict adverse cardiac events in DMD/BMD patients?
Do impaired LV systolic function and transmural LGE predict adverse cardiac events in DMD/BMD patients?
In DMD/BMD patients, impaired LV-EF and transmural LGE independently and additively predict adverse cardiac events, even when LV-EF is relatively preserved.
May support risk stratification in DMD/BMD cardiomyopathy; leaves open whether fibrosis-targeted therapies alter outcomes.
An impaired LV systolic function (LV-EF ≤45%) and a "transmural" pattern of myocardial fibrosis independently predict the occurrence of adverse cardiac events in DMD/BMD patients. Even in DMD/BMD patients with relatively preserved LV-EF (>45%), the simple and visually assessable parameter "transmural LGE" is of additive prognostic value.
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Florian et al. (2014) studied this question.
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