Why the study?
Does substrate modification combined with pulmonary vein isolation improve ablation success rates in patients with persistent atrial fibrillation?
Does substrate modification combined with pulmonary vein isolation improve ablation success rates in patients with persistent atrial fibrillation?
Adding substrate modification (left linear lesions) to pulmonary vein isolation significantly improves ablation success rates in patients with persistent atrial fibrillation.
Warrants adding left linear lesions to PVI in persistent AF; extends RCT evidence for substrate modification.
PVI alone is insufficient in the treatment of persistent AF. However, additional left linear lesions increase the success rate significantly. Early AF-relapses are associated with a negative outcome after PVI alone but not following additional SM.
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Willems et al. (2006) studied this question.
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