Iatrogenic atrial septal defects are common (41%) in the long term after mitral valve TEER and are associated with improved hemodynamics but low overall clinical impact.
iASDs after TEER warrant no routine closure; leaves open whether hemodynamic gains affect hard outcomes in prospective studies.
Prevalence of iASDs after TEER in long-term follow-up was about 41%. Although a significant reduction of sPAP and better left atrial reverse remodelling were accomplished in patients with iASD, clinical impact appears low. Manipulation at the atrial septum might play a key role in creating persisting iASD.
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Paukovitsch et al. (2021) studied this question.
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