In a goat model of AF, endo-epicardial electrical dissociation increases due to progressive uncoupling, which correlates with the stability and complexity of the AF substrate.
Findings in goat AF model should not yet inform practice; hypothesis-generating for endo-epicardial uncoupling in human AF.
During AF, pronounced dissociation of electrical activity occurs between the epicardial layer and the endocardial bundle network. The increase in dissociation is due to owing to progressive uncoupling between the epicardial layer and the endocardial bundles and correlates with increasing stability and complexity of the AF substrate.
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Eckstein et al. (2010) studied this question.