Why the study?
Are voltage-gated calcium currents augmented in mesenteric artery smooth muscle cells of spontaneously hypertensive rats compared to normotensive controls?
Population
Single myocytes acutely isolated from mesenteric artery branches of 20-week-old spontaneously hypertensive…
Comparison
Whole-cell patch-clamp measurement of… vs Myocytes from normotensive Wistar-Kyoto rats (WKY)
Design
Preclinical
Authors
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Does not support altering calcium channel blocker use; leaves open translation from rat models to human hypertension.
Are voltage-gated calcium currents augmented in mesenteric artery smooth muscle cells of spontaneously hypertensive rats compared to normotensive controls?
Spontaneously hypertensive rats exhibit augmented calcium influx through L-type calcium channels in arterial smooth muscle, providing a mechanistic basis for the greater efficacy of calcium channel blockers in hypertension.
Cox et al. (1995) studied this question.
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