Why the study?
Do patients with HFpEF and normal natriuretic peptide levels have an increased risk of death or HF readmissions compared to patients without HF?
Do patients with HFpEF and normal natriuretic peptide levels have an increased risk of death or HF readmissions compared to patients without HF?
HFpEF patients with normal natriuretic peptide levels still face an increased risk of mortality and HF readmissions compared to those without HF, highlighting the clinical importance of recognizing this phenotype.
Normal NP HFpEF may warrant closer surveillance than no HF; leaves open optimal management and prospective validation of this phenotype.
Patients with HFpEF and normal NP display mild diastolic dysfunction and preserved CO reserve during exercise, despite marked elevation in filling pressures. While clinical outcomes are not as poor compared with patients with high NP, patients with normal NP HFpEF exhibit increased risk of death or HF readmissions compared with patients without HF, emphasizing the importance of this phenotype.
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Verbrugge et al. (2021) studied this question.
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