Why the study?
Does once-daily oral aliskiren lower blood pressure effectively and safely compared to irbesartan and placebo in patients with mild-to-moderate hypertension?
Does once-daily oral aliskiren lower blood pressure effectively and safely compared to irbesartan and placebo in patients with mild-to-moderate hypertension?
Once-daily oral aliskiren provides effective blood pressure lowering comparable to irbesartan 150 mg, with placebo-like tolerability in patients with mild-to-moderate hypertension.
Aliskiren offers a direct renin inhibitor option for mild-to-moderate hypertension; confirms efficacy comparable to ARBs in an RCT.
Once-daily oral treatment with aliskiren lowers blood pressure effectively, with a safety and tolerability profile comparable to that of irbesartan and placebo, in patients with mild-to-moderate hypertension. Aliskiren 150 mg is as effective as irbesartan 150 mg in lowering blood pressure.
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Gradman et al. (2005) studied this question.
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