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October 16, 2015Pharmaceutical BiologyOpen Access

Ameliorative effect of naringin against doxorubicin-induced acute cardiac toxicity in rats

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Why the study?

Does naringin prevent doxorubicin-induced cardiomyopathy in rats?

Population

rats with doxorubicin-induced acute cardiac toxicity

Design

Preclinical

Authors

MKMohit KwatraJohns Hopkins UniversityVKVikas KumarAll India Institute of Medical Sciences RaipurAJAshok JangraCentral University of Haryana

Discussion

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Implication

Does not support clinical use with doxorubicin; hypothesis-generating for naringin cardioprotection in humans.

Structured PICO

Does naringin prevent doxorubicin-induced cardiomyopathy in rats?

P
Population
rats with doxorubicin-induced acute cardiac toxicity
I
Intervention
naringin (NR) in combination with doxorubicin (Dox)
O
Outcome
cardioprotective effect against Dox-induced cardiomyopathy

Naringin may offer cardioprotection against doxorubicin-induced acute cardiac toxicity in a rat model.

Cite This Study

Kwatra et al. (2015) studied this question.

synapsesocial.com/papers/69d5725075589c71d767e6fdhttps://doi.org/10.3109/13880209.2015.1070879
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Role of superoxide, nitric oxide, and peroxynitrite in doxorubicin-induced cell death in vivo and in vitro2009 · 384 citations
  2. 2Doxorubicin cardiotoxicity may be caused by its metabolite, doxorubicinol.1988 · 356 citations
  3. 3Doxorubicin cardiotoxicity: analysis of prevailing hypotheses1990 · 692 citations
  4. 4The iron(III)-adriamycin complex inhibits cytochrome <i>c</i> oxidase before its inactivation1988 · 32 citations