Why the study?
Do higher doses of beta-blockers and ACEi/ARB improve long-term survival in patients after CRT implantation?
Do higher doses of beta-blockers and ACEi/ARB improve long-term survival in patients after CRT implantation?
Higher doses of guideline-directed medical therapy (beta-blockers and ACEi/ARB) after CRT implantation are associated with improved long-term survival.
Supports GDMT optimization post-CRT; leaves open causality and need for randomized confirmation.
After CRT implantation, optimization of HF treatment is possible, and long-term adherence to HF medication remains high. Higher doses of BB and ACEi/ARB were associated with prolonged survival.
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Witt et al. (2015) studied this question.
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