Why the study?
Do natriuretic peptides accurately detect diastolic dysfunction and heart failure with preserved ejection fraction?
Do natriuretic peptides accurately detect diastolic dysfunction and heart failure with preserved ejection fraction?
Natriuretic peptides are clinically useful for ruling out, rather than definitively diagnosing, diastolic dysfunction and HFpEF.
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Supports NP use to rule out DD/HFpEF in practice; confirms limited diagnostic utility in meta-analysis.
The diagnostic performance of NPs for the detection of DD and HFpEF is reasonable. However, they may be used to rule out DD or HFpEF, and not for the diagnosis of DD or HFpEF.
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Remmelzwaal et al. (2020) studied this question.
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