Why the study?
Heart failure development in aortic stenosis is multifactorial, making the delineation of determinants of admissions crucial for identifying high-risk individuals before left ventricular function is impaired.
Design
Review
Does not yet support routine integration of imaging and biomarkers for aortic stenosis timing decisions; leaves open prospective validation trials.
HF development in AS is multifactorial and its link to left ventricular dysfunction is a complex process. Delineating the determinants of HF admissions in AS is crucial for identifying individuals at high risk. Identifying the early signs of left ventricular decompensation by using surrogate markers may be the key, even before left ventricular function becomes impaired. Translating multimodality imaging techniques and biomarkers into routine clinical practice for evaluating cardiac damage and integrating these markers with patient and procedural factors that affect HF before and after AVR can facilitate timely intervention, minimizing the likelihood of HF progression and influencing future guidelines.
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Mengi et al. (2024) studied this question.
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