Why the study?
Do ACE inhibitors improve outcomes compared to diuretics in older subjects with hypertension?
Do ACE inhibitors improve outcomes compared to diuretics in older subjects with hypertension?
ACE inhibitors may provide better clinical outcomes than diuretics in older hypertensive patients, especially men, independent of the degree of blood pressure reduction.
Should not yet change prescribing in older hypertensive patients; leaves open whether ACE inhibitors outperform diuretics in randomized trials.
Initiation of antihypertensive treatment involving ACE inhibitors in older subjects, particularly men, appears to lead to better outcomes than treatment with diuretic agents, despite similar reductions of blood pressure.
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Wing et al. (2003) studied this question.
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