Why the study?
Does exercise training have different effects in rats with stable versus progressive pulmonary hypertension?
Does exercise training have different effects in rats with stable versus progressive pulmonary hypertension?
Exercise training is beneficial in stable pulmonary hypertension but detrimental in progressive pulmonary hypertension in a rat model.
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Urges caution with exercise in progressive PH; leaves open translation of stage-specific effects to humans.
In our rat model, exercise training was found to be beneficial in stable PH but detrimental in progressive PH. Future studies are necessary to address the clinical implications of our findings.
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Handoko et al. (2009) studied this question.
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