Why the study?
Does a prolyl 4-hydroxylase inhibitor improve left ventricular function and attenuate left ventricular enlargement in adult female rats after experimental myocardial infarction?
Does a prolyl 4-hydroxylase inhibitor improve left ventricular function and attenuate left ventricular enlargement in adult female rats after experimental myocardial infarction?
Inhibition of collagen synthesis with a prolyl 4-hydroxylase inhibitor partially recovers left ventricular function and alters the pattern of left ventricular enlargement post-myocardial infarction in a rat model.
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May support prolyl 4-hydroxylase inhibition post-MI; leaves open translation to human LV remodeling.
Nwogu et al. (2001) studied this question.
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