Does digoxin increase all-cause mortality in patients with atrial fibrillation?
Digoxin use in patients with atrial fibrillation is associated with increased all-cause mortality, calling its widespread use into question.
Digoxin was associated with a significant increase in all-cause mortality in patients with AF after correcting for clinical characteristics and comorbidities, regardless of gender or of the presence or absence of HF. These findings call into question the widespread use of digoxin in patients with AF.
Whitbeck et al. (2012) studied this question.