Why the study?
If NT-proBNP is used for general population screening, interpreting levels will require age- and sex-specific thresholds to identify potential pathophysiology.
If NT-proBNP is used for general population screening, age- and sex-specific thresholds are required to accurately identify potential pathophysiology.
May warrant age- and sex-specific NT-proBNP thresholds for screening; leaves open whether adjusted cutoffs improve risk stratification in low-risk populations.
An NT-proBNP ≥125 pg/mL is common in females without classical cardiovascular risk factors as well as older people. If NT-proBNP becomes widely used for screening in the general population, interpretation of NT-proBNP levels will require that age and sex-specific thresholds are used to identify patients with potential pathophysiology.
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Welsh et al. (2022) studied this question.
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