If NT-proBNP is used for general population screening, age- and sex-specific thresholds are required to accurately identify potential pathophysiology.
An NT-proBNP ≥125 pg/mL is common in females without classical cardiovascular risk factors as well as older people. If NT-proBNP becomes widely used for screening in the general population, interpretation of NT-proBNP levels will require that age and sex-specific thresholds are used to identify patients with potential pathophysiology.
Welsh et al. (Sat,) studied this question.