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February 1, 1968Circulation ResearchOpen Access

Acute Vascular Endothelial Changes Associated with Increased Blood Velocity Gradients

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Authors

DFDonald L. FryGeneral / Preventive / Lipids

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Implication

Randomized trial quantifies endothelial changes due to increased blood velocity in dogs, indicating significant vascular effects.

Key Points

  • To quantify acute endothelial histological changes associated with increased blood velocity.
  • Designed a nontraumatic intra-aortic device to narrow aortic blood flow in dogs.
  • Developed techniques to measure shearing stress on endothelial surfaces along the thoracic aorta.
  • Conducted cell count assessments to establish normal endothelial cell populations based on stress exposure.
  • Acute yield stress for endothelial cells was identified as 379±85 dynes/cm².
  • Excessive stress exposure led to endothelial cell swelling, deformation, and disintegration within one hour.
  • Documented deterioration of the endothelial surface correlated positively with increased shearing stress.

Cite This Study

Donald L. Fry (1968) studied this question.

synapsesocial.com/papers/69d75da2f182769aa8b8ab7ahttps://doi.org/10.1161/01.res.22.2.165
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