What question did this study set out to answer?

To provide an updated assessment of global liver disease mortality, etiology trends, and geographic disparities since the 2019 benchmark.

March 27, 2023Journal of HepatologyOpen Access

Global burden of liver disease: 2023 update

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Authors

HDHarshad Devarbhavi SASumeet K. Asrani JAJuan Pablo Arab

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Overview

Epidemiological review reports two million annual deaths from liver conditions globally, highlighting the rising burden of cirrhosis and fatty liver disease.

Key Points

To provide an updated assessment of global liver disease mortality, etiology trends, and geographic disparities since the 2019 benchmark.
Synthesized updated global epidemiological data through 2023 on liver disease mortality and etiology.
Evaluated shifts across alcohol-associated liver disease, non-alcoholic fatty liver disease, viral hepatitis, and hepatocellular carcinoma.
Conducted a targeted regional assessment addressing liver disease epidemiology in Africa.
Liver disease accounts for 2 million deaths annually (4% of all worldwide deaths, or 1 in 25), with approximately two-thirds occurring in men.
Mortality is driven predominantly by complications of cirrhosis and hepatocellular carcinoma, with viral hepatitis, alcohol use, and non-alcoholic fatty liver disease as primary drivers.
Acute hepatitis remains primarily caused by hepatotropic viruses, though drug-induced liver injury accounts for an increasing proportion of cases.

Cite This Study

Devarbhavi et al. (2023) studied this question.

synapsesocial.com/papers/69d76dbdf44a16d01ef30f55 https://doi.org/10.1016/j.jhep.2023.03.017

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March 27, 2023Journal of HepatologyOpen Access

Global burden of liver disease: 2023 update

View Full Paper

Ask AI

Bookmark

Authors

HDHarshad Devarbhavi SASumeet K. Asrani JAJuan Pablo Arab

Discussion

Member takes

Overview

Epidemiological review reports two million annual deaths from liver conditions globally, highlighting the rising burden of cirrhosis and fatty liver disease.

Key Points

To provide an updated assessment of global liver disease mortality, etiology trends, and geographic disparities since the 2019 benchmark.
Synthesized updated global epidemiological data through 2023 on liver disease mortality and etiology.
Evaluated shifts across alcohol-associated liver disease, non-alcoholic fatty liver disease, viral hepatitis, and hepatocellular carcinoma.
Conducted a targeted regional assessment addressing liver disease epidemiology in Africa.
Liver disease accounts for 2 million deaths annually (4% of all worldwide deaths, or 1 in 25), with approximately two-thirds occurring in men.
Mortality is driven predominantly by complications of cirrhosis and hepatocellular carcinoma, with viral hepatitis, alcohol use, and non-alcoholic fatty liver disease as primary drivers.
Acute hepatitis remains primarily caused by hepatotropic viruses, though drug-induced liver injury accounts for an increasing proportion of cases.

Cite This Study

Devarbhavi et al. (2023) studied this question.

synapsesocial.com/papers/69d76dbdf44a16d01ef30f55 https://doi.org/10.1016/j.jhep.2023.03.017

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