What question did this study set out to answer?

Determine whether acute hyperglycemia raises circulating inflammatory cytokines and assess the role of oxidative mechanisms in individuals with normal and impaired glucose tolerance.

October 15, 2002Circulation

Inflammatory Cytokine Concentrations Are Acutely Increased by Hyperglycemia in Humans

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Authors

KEKatherine EspositoPreventive Cardiology FNFrancesco NappoUniversity of Campania "Luigi Vanvitelli"RMRaffaele MarfellaPreventive Cardiology

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Implication

Experimental study demonstrates acute hyperglycemia increases cytokine levels in humans, indicating a causal role in diabetic immune activation.

Key Points

Determine whether acute hyperglycemia raises circulating inflammatory cytokines and assess the role of oxidative mechanisms in individuals with normal and impaired glucose tolerance.
Assessed circulating cytokine concentrations in response to acute hyperglycemia in human subjects.
Compared cytokine response magnitudes between individuals with normal glucose regulation and those with impaired glucose tolerance (IGT).
Acute hyperglycemia directly increased circulating concentrations of inflammatory cytokines via an oxidative mechanism.
Cytokine increases were significantly more pronounced in participants with impaired glucose tolerance.

Cite This Study

Esposito et al. (2002) studied this question.

synapsesocial.com/papers/69d7ca1333ca018b39ae2d38 https://doi.org/10.1161/01.cir.0000034509.14906.ae

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Implication

Experimental study demonstrates acute hyperglycemia increases cytokine levels in humans, indicating a causal role in diabetic immune activation.

Inflammatory Cytokine Concentrations Are Acutely Increased by Hyperglycemia in Humans

Discussion

Member takes

Implication

Key Points

Cite This Study

Inflammatory Cytokine Concentrations Are Acutely Increased by Hyperglycemia in Humans

Discussion

Member takes

Implication

Key Points

Cite This Study

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