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Engineering design study reveals a low-power closed-loop neurostimulation system for deep brain stimulation, highlighting potential for advanced neurological disorder treatments.
This paper describes a neurostimulation IC for use in advanced closed-loop neurostimulation applications, such as deep brain stimulation (DBS) for treatment and research of neurological disorders including Parkinson's disease. This system senses and filters neural activity with eight pre-amplifiers, a 200 kS/s 8-bit log ADC and digital filters and incorporates 64 programmable current-stimulation channels. The entire device, implemented in 0.18 μm CMOS, occupies 2.7 mm 2 and consumes 89 μW in normal operation mode and 271 μW in configuration mode from a 1.8 V supply.
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Lee et al. (2010) studied this question.
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