What question did this study set out to answer?

To determine whether the urinary protein-to-creatinine ratio in untimed spot urine samples reliably estimates 24-hour urinary protein excretion in healthy individuals and patients with renal disease.

February 1, 1987Clinical ChemistryOpen Access

Proteinuria in health and disease assessed by measuring the urinary protein/creatinine ratio.

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Authors

JLJ. LemannMilwaukee County Medical Complex BDB T Doumas

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Implication

Diagnostic study reveals strong correlation between spot and 24-hour urinary protein-to-creatinine ratios across diverse cohorts, indicating spot tests reliably assess kidney function.

Key Points

To determine whether the urinary protein-to-creatinine ratio in untimed spot urine samples reliably estimates 24-hour urinary protein excretion in healthy individuals and patients with renal disease.
Measured daily protein excretion and protein/creatinine ratios in 24-hour and untimed urine specimens across 112 participants (60 healthy adults, 30 patients with kidney disease, and 22 kidney-transplant recipients).
Compared the correlation between spot and 24-hour urinary protein/creatinine ratios across excretion ranges from 44 mg/day to 19,300 mg/day.
Protein/creatinine ratios in untimed and 24-hour urine samples were closely correlated (r = 0.97) across normal (mean 44 mg/day) to nephrotic (up to 19,300 mg/day) excretion rates.
Healthy subjects consistently maintained urinary protein/creatinine ratios below 100 mg/g, establishing a benchmark for normal renal function.
Patients with nephrotic syndrome (protein excretion ≥4000 mg/day) consistently exhibited ratios exceeding 2000 mg/g, while intermediate ratios (100 to 2000 mg/g) corresponded to other forms of kidney disease.

Cite This Study

Lemann et al. (1987) studied this question.

synapsesocial.com/papers/69d95e8d5e5bcb4e3b835d63 https://doi.org/10.1093/clinchem/33.2.297

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Implication

Diagnostic study reveals strong correlation between spot and 24-hour urinary protein-to-creatinine ratios across diverse cohorts, indicating spot tests reliably assess kidney function.

Proteinuria in health and disease assessed by measuring the urinary protein/creatinine ratio.

Discussion

Member takes

Implication

Key Points

Cite This Study

Proteinuria in health and disease assessed by measuring the urinary protein/creatinine ratio.

Discussion

Member takes

Implication

Key Points

Cite This Study

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